An epigenetic study suggests that altered immune processes contribute to chronic fatigue syndrome
High rates of epigenetically altered immune regulating genes suggested ME/CFS patient’s immune systems are skewed to a Th2 immune response. Altered methylation rates in the genes involved in regulating the adaptive immune response (T and B cells) could help explain the inflammation present in ME/CFS.
The authors highlighted a few genes that had been epigenetically altered. One hypermethylated gene (BCL10) in the ME/CFS patients activates a transcription factor called NF-kB that’s responsible for triggering a wide inflammatory response. Maes has proposed that the NF-kB inflammatory pathway is enhanced in both ME/CFS and depression. Another epigenetically altered gene in ME/CFS is associated with EBV infection of B-cells.
Why do we know this kind of stuff about this damn illness and yet still the only treatment I am offered is 99% geared towards psychological issues? *sigh*